The club spent over fifty years in Senior football, and qualified for the Scottish Cup on twenty occasions.

Their greatest run came in the 1890–91 competition where they reached the fifth round before losing to Celtic in front of a record crowd of 5,000 at their Raploch Park ground.

[3][4] In the same season, centre half John Clelland became the clubs' one and only full Scotland international when he was capped against Ireland in March 1891.

[15] Some notable players in the Junior era to step up from the club include Bobby Hogg (Celtic) and John Martis (Motherwell) with both playing for Scotland later in their careers, George Miller, who won the Scottish Cup in 1961 with Dunfermline Athletic and Davie White who played for and managed Clyde before managing Rangers.

The club moved to the Robert Smillie Memorial Park in 1964 but were forced to vacate this ground at the end of the 2006–07 season as it was demolished in order to re-develop Larkhall Academy.