[1] Several University of Alberta Faculty of Medicine & Dentistry departments are headquartered in the Royal Alexandra Hospital including Ophthalmology & Visual Sciences[3] and Obstetrics & Gynecology.

The Eye Institute of Alberta offers specialized care and treatment for a variety of ophthalmologic conditions.

[5] The CK Hui Heart Centre specializes in the non-surgical treatment of coronary artery disease, as well as interventional cardiology.

The Centre performs minimally invasive interventional cardiac procedures and hosts a number of progressive programs focusing on prevention, stabilization, multicultural needs, rehabilitation, maternal heart health and angina.

[8] The hospital is home to Canada's first Da Vinci surgical robot dedicated to women's health allowing for minimally invasive urogynecological and gynecological surgeries.

CAMIS provides a place for research in the clinical experience and improvements of minimally invasive surgery.

[10] The Alberta Thoracic Oncology Program (ATOP) operates a Rapid Access Clinic at the Royal Alexandra Hospital.

In 1967 the Children's Pavilion was established, with Princess Alexandra of Kent (cousin of Queen Elizabeth II) cutting the ribbon at the opening ceremonies.

On December 6, 1981, a North American Road Ltd. Mitsubishi MU-2 (C-GLOW) arriving to Edmonton from Fort McMurray International Airport crash landed in the unoccupied sixth floor of the Royal Alexandra Hospital.

[17] The Royal Alexandra Hospital opened the first hospital-based safe consumption site in North America in 2018.

Psychiatry programs for children, adolescents and adults are all in substandard spaces that present risks to patients and to staff.

There are large psychiatry/mental health populations served by RAH but there are insufficient or inadequate spaces for program delivery.

Stephen Mendel, made the announcement that the Royal Alexandra Hospital would receive the funding needed to rebuild;[24] however, the Progressive Conservative Party lost the provincial election months after this announcement and the allocation of this funding to the Royal Alexandra Hospital was temporarily removed by Premier Rachel Notley's New Democratic Party in 2015 in order to reassess all capital region hospitals as a whole[25][26][27] despite campaigning on the inadequacies of the facility.

The Foundation has been involved in a variety of major campaigns for the Royal Alexandra Hospital site such as the building of Robbins Pavilion, the CK Hui Heart Centre, and renovations to the Eye Institute of Alberta.