It is owned and run by the Hampshire Hospitals NHS Foundation Trust.

Florence Nightingale advised on the construction on this new site and the architect William Butterfield designed the new hospital, which opened in 1868 with sixteen in-patients and fourteen out-patients.

The A&E Department next door survived, but was closed overnight, opening only for minor injuries the following night for several days until CT Scanning facilities were made available.

[7] In January 2012, the Basingstoke and North Hants Hospitals NHS Foundation Trust merged with the Winchester and Eastleigh NHS Trust; forming a combined organisation henceforward called Hampshire Hospitals NHS Foundation Trust.

[8] In September 2021, the Winchester Hospice opened on the site with 10 inpatient beds.