The series is based in part on contemporary concierge medicine practices of independent doctors and companies and follows Hank Lawson, an unfairly discredited but brilliant diagnostic surgeon, who moves to the Hamptons with his brother Evan as he works as a concierge doctor to the uber rich and ultra elite.

The cast of the show includes Mark Feuerstein, Paulo Costanzo, Reshma Shetty, Brooke D'Orsay, Ben Shenkman, Jill Flint, and Campbell Scott.

Although actually located 60 miles to the west, in Huntington, Oheka served as the Hamptons home of Boris, the German nobleman who offers his guest house to Hank and Evan.

In one episode, a Long Beach drive-through convenience store, Dairy Barn, was used as a fictional hot dog stand;[citation needed] a sign can be seen in the opening of that scene.

Other places used as fictional Hamptons locations include Northport Village in the Town of Huntington, Old Westbury Gardens, Freeport's Nautical Mile, which served as the exterior and parking lot of Hampton Heritage Hospital (in one scene, Freeport's charter coat can be seen across the bay) Caumsett State Historic Park[citation needed] and Oyster Bay Town Hall, which was transformed into the entrance of the Hamptons Heritage Hospital emergency room.

Lyle published two novels based on the television series, under Signet Books' Obsidian imprint.

The two brothers also claimed that a USA Network executive told them, "prior to learning about Housecall, he was unaware of concierge doctors and that he thought it was a fascinating idea."

The decision was reversed on appeal in June 2012, the court holding that Christensens' claims were not pre-empted by copyright law.