[4] In May 2017, she received the Alumni Award for Artistic Achievement at the Rhode Island School of Design commencement ceremony.

In a 2006 interview with comedian Steve Martin for the New Yorker Festival, Chast revealed that she enjoys drawing interior scenes, often involving lamps and accentuated wallpaper, to serve as the backdrop for her comics.

[11] Her New Yorker cartoons began as small black-and-white panels, but increasingly used more color and often appeared over several pages.

[12] Chast has written or illustrated more than a dozen books, including Unscientific Americans, Parallel Universes, Mondo Boxo, Proof of Life on Earth, The Four Elements and The Party After You Left: Collected Cartoons 1995–2003 (Bloomsbury, 2004).

is a graphic memoir, combining cartoons, text, and photographs to tell the story of an only child helping her elderly parents navigate the end of their lives.

[15] Chast lives in Ridgefield, Connecticut[16][17][18] with her husband, humor writer Bill Franzen.