Rozhyshche (Ukrainian: Рожище, IPA: [ˈrɔʒɪʃtʃe]; Polish: Rożyszcze; Yiddish: ראזשישטש, romanized: Rozhishch) is a city in Volyn Oblast, in north-western Ukraine.

In 1795, as a result of the Third Partition of Poland, the settlement was annexed by the Russian Empire, within which it was administratively located in Lutsky Uyezd in Volhynian Governorate.

It saw an influx of Jews as a result of Russian discriminatory policies (see Pale of Settlement).

In the interwar period, it was the seat of a gmina, administratively located in the Łuck County in the Wołyń Voivodeship of Poland.

According to the 1921 census, the town's population was 79.8% Jewish, 9.2% Polish, 5.7% German, 4.1% Ukrainian.