The Rua do Guarda-Mor (Portuguese for "Street of the chief archivist") is a street in Lisbon, Portugal, which formerly belonged to the parish (freguesia) of Santos-o-Velho, more precisely to the sub-parish of Madragoa.

Following the 2012 Lisbon Administrative Reform, the street now belongs to the newly created parish of Estrela.

Already in 1565 the street is mentioned as Rua do Guarda-Mor de Alfandega in the Livro do Lançamento.

[1] Bernardo Gomes de Brito, Portuguese historian and scholar, refers to it as a main artery road of Lisbon of the sixteenth century.

The street's name derives from the nobleman Manuel de Sande, Guarda-Mor da Alfandega, who lived there together with his wife and daughter.