Hossain is also the founder Sultana's Dream, a funding and mentorship grant to empower, promote and support the next generation of women filmmakers and storytellers in Bangladesh.

[6] Hossain debuted as a feature filmmaker in 2011 with Meherjaan, a film about a Bengali woman's love affair with a Pakistani soldier during Bangladesh's 1971 war of independence.

[15] Made in Bangladesh was listed in criterion collections hidden-gems of the 2010s as "The storytelling in the film is like the lead character—quiet, methodical, and tenacious, reminiscent of the great director Satyajit Ray."

[17][18] Hossain and her partner Ashique Mostafa established Khona Talkies in 2008 with the vision of using young Bangladeshi talent to produce films in a local terrain with possible foreign co-production and creative tie-ups.

Since its inception, Khona Talkies has produced a few award-winning and internationally acclaimed as well as locally significant independent films by young filmmakers.

For its pilot run, the program selected a cohort of 16 emerging women filmmakers who would receive basic filmmaking training across disciplines and guidance for preparing project dossiers and pitching, leadership workshops, script-writing modules, study circles encompassing feminist film history, the female gaze and gendered reading of film texts.