Constructed in the late nineteenth century for a prominent local pharmacist, it now abuts a city hospital, but it has been named a historic site.

[2]: 126  Pretzinger's American-born younger brother Albert, one of Dayton's leading architects,[2]: 978  designed the house, which was completed in 1889.

A hip roof covers the house, interrupted at points by small gables with miniature Palladian windows.

While the house remains at the intersection of Main and Apple Streets,[1] as it was during Pretzinger's lifetime,[2]: 129  the property no longer extends south to Wyoming; most of his land is now the site of Miami Valley Hospital.

[5] Two other National Register-listed locations lie within a few minutes' walk: the former Eagles Building to the north, and the exposition hall at the county fairgrounds across the street to the southwest.