Prior to becoming a physician, he served as a flight surgeon in the United States Air Force for more than 21 years, earning the rank of colonel, the highest position awarded to an American of Haitian descent at that time.

[3] Moise relocated to Miami sometime during the 1980s, and had earned a federal grant for his medical studies where he devoted several years of practice to a community that saw a large influx of Haitian refugees, that had been underserved and lacked enough doctors who spoke Creole.

[3] To fulfill his requirements for a federal grant for medical studies, he worked for four years in a Miami clinic in a community with a large number of Haitian refugees, that had been underserved, and lacked enough doctors who spoke Creole.

[3] After four years, he started his own practice in an 800 square-foot storefront in North Miami, which grew into a Comprehensive Health Center with several locations amassing to 10,000 square-footage.

Running for the state's 24th congressional district in 2012, Moise fell short again at a one-on-one chance against Frederica Wilson, who had been endorsed by President Obama .

[24] In January 2010, Moise traveled to Haiti with a Disaster Rescue Team two days after the country was struck with a major earthquake, saving 11 lives.

[citation needed] Moise was criticized in 2009 for his likeness being used for the historical Haitian monument at Franklin Square in Savannah, Georgia.

Moise agreed to the request for funds and mentioned that sculptor James Mastin had asked him to sit for the piece because of his past experience as a magazine model.