[1] Over the course of his long big league career, he has played for many teams, including the Cleveland Indians, San Diego Padres (four separate stints), Los Angeles Dodgers (twice), Atlanta Braves (twice), Texas Rangers, Boston Red Sox (twice), Kansas City Royals, Florida Marlins, and Philadelphia Phillies.

On September 29 2004 while pitching for the Florida Marlins Seánez recorded the final out at Montreal's Olympic Stadium when he got Terrmel Sledge to pop out to third base to end the final Montreal Expos home game before the team became the Washington Nationals in 2005 Seánez' best season came in 2005 with the San Diego Padres.

He posted a 7–1 record with a 2.69 ERA, setting career highs in wins (7), games pitched (57), innings (60.1) and strikeouts (84).

Seánez showed ability to overcome numerous injuries, combining weightlifting with mixed martial arts during his off-season workout regimen.

He did a better job than many middle relievers at holding on base runners, and was a competent fielder despite a history of back problems.