The Rue Mercière (French pronunciation: [ʁy mɛʁsjɛʁ]) is a street of Les Cordeliers quarter in the 2nd arrondissement of Lyon.

[2] In the 16th century, it was the street of printers and notably housed Sébastien Gryphe's workshop, at the corner of the Rue Thomassin.

By the mid 19th century, the street was covered with asphalt and all buildings in the eastern part were deleted when the Rue Centrale was created.

[5] The project of F. Chollat, with his 5th prize, wanted to build in the street Mercière a modern quarter and a fifty-stage skyscraper.

The northern part of the street was demolished between the street and the dock to create a major building project : Mr. Marot, chief architect of the Bâtiments Civils et Palais Nationaux, elaborated a project modified eighteen times to "protect the variety of appearance and fancy which were the charm of the old neighborhood".

In the south, it currently houses a large number of restaurants, including many bouchons of Lyon and bars, making the street a popular quarter for the tourists.

Between the Rue Grenette and the luxurious hotel Horace Cardon, the street is narrower, with on the west, a row of Renaissance-styled houses with mullioned windows.

[5] A plaque shows the location of Étienne Dolet's print shop (16th century), another one from the Hospices Civils de Lyon is attached to the printer and alderman Guillaume de Rouville's house, and another one is on the Hôtel Horace Cardon mentioning 18th-century printer Fleury Mesplet.