The Rue Saint-Denis (French pronunciation: [ʁy sɛ̃ dəni]) is one of the oldest streets in Paris.

The ancient Roman route (Flanders road) leading to Saint-Denis, Pontoise and Rouen competed with the Route de Senlis (Rue Saint-Martin) but gained an advantage over it with the demolition of the Grand Pont (see Pont au Change) and the development of the royal Abbey of Saint-Denis, becoming the triumphal way for royal entries into the capital.

The street was one of the centres of the June Rebellion of 1832, immortalised in Victor Hugo's novel Les Misérables, and which is referred to in the book as the "Epic of the Rue Saint-Denis".

[1] The street contains clothes shops, bars and restaurants, the church of Saint-Leu-Saint-Gilles, a bank, and the Chambre des notaires building.

For many decades, the Rue Saint-Denis and it surrounding neighborhood were famous for the prostitution trade that took place there.