The Rue Saint-Jacques (French pronunciation: [ʁy sɛ̃ ʒak]) is a street in the Latin Quarter of Paris.

Formerly lying along the cardo of Roman Lutetia, this street was a main axial road of medieval Paris, as the buildings that still front it attest.

However, the introduction of the Boulevard Saint-Michel, constructed through this old quarter of Paris by Baron Haussmann, relegated the roughly parallel Rue Saint-Jacques to a backstreet.

Johann Heynlin and Guillaume Fichet established the first printing press in France, briefly at the Sorbonne and then on this street, in the 1470s.

The second printers in Paris were Peter Kayser and Johann Stohl at the sign of the Soleil d'Or in the Rue Saint-Jacques, from 1473.