The Rue de Gadagne (French pronunciation: [ʁy d(ə) ɡadaɲ]) is a paved pedestrian street in the Saint-Jean quarter, in the 5th arrondissement of Lyon, France.

The street belongs to the zone classified as a World Heritage Site by UNESCO.

[6] Gadagne brothers, Thomas, Lord de Beauregard, and Guillaume, seneschal of Lyon in 1564, were Italian bankers.

[5] Very representative of the Renaissance architecture of the neighborhood, the street is wide in front of the City Hall of the fifth arrondissement which is the former Jesuit college, and much more narrow in its northern part.

At the corner of the Rue de la Fronde, a statue of St. Anne can be seen, and four small old houses are open by ten arches aligned on the western side of the street.