His father King Cyamatare and members of his family were brutally murdered by Nyebunga and his allies.

The fall of King Ndahiro I Cyamatare occurred shortly after his son fled to the neighboring Kingdom of Karagwe.

Ruganzu, who is said to have left a mark on the Rwanda region, who is said to have returned in 1510 from the kingdom of Karagwe ka Bahinda, where he had been exiled with his aunt Nyabunyana and came to liberate Rwanda from the hands of foreigners after eleven years exile, young and inexperienced.

Ruganzu also strengthened bilateral relations between Rwanda and Karagwe, where his aunt was a queen who protected him and taught him to fight.

Ruganzu died from the shooting of an arrow in the eye by a man named Bitibibisi from Rusenyi (modern Karongi).