The rugby sevens at the 2010 Commonwealth Games was the fourth Commonwealth Games at which rugby sevens was played.

[1] Rugby sevens was one of only two sports contested only by males with no women's competition (the other being boxing).

[1] Namibia withdrew and was later replaced by Malaysia.

Due to the withdrawal, Uganda was shifted to Group D while Malaysia was placed in Group C.[2] Fiji, described as "perennial crowd favourites", was absent, due to the country being suspended from the Commonwealth following the 2006 military coup.

[3] There were security and health concerns surrounding the 2010 Commonwealth Games, but many main competitors had confirmed their participation.