Laura Linney, Nancy Travis, Faye Dunaway, and Teri Hatcher also star as Pryce's current or former love interests who have had a major influence on his success so far, but who also have a great deal of control over his decisions.

Created for Turner Entertainment, Running Mates was initially aired on TNT on the night of August 13, 2000, and has since been broadcast in Australia, Hungary, Iceland, and Sweden.

As a front-runner for the Democratic Party presidential candidate, Pryce owes the success of his campaign to his manager Lauren Hartman (Laura Linney) and his wife Jennifer (Nancy Travis).

All four women are seemingly more intent on exerting control over Pryce and winning their own personal battles against each other rather than honestly trying to help him make the correct political decision.

Running Mates was intended to give the viewers a somewhat realistic although humorous and exaggerated insight into politics and decision-making of presidential campaigns, so Gerald Rafshoon was brought on board.