45 (2016 population: 292) is a rural municipality (RM) in the Canadian province of Saskatchewan within SARM Division No.

Located in the southwest portion of the province, it is adjacent to the United States border, neighbouring Valley County and Phillips County in Montana.

In the 2021 Census of Population conducted by Statistics Canada, the RM of Mankota No.

45 is governed by an elected municipal council and an appointed administrator that meets on the second Tuesday of every month.

[3] The reeve of the RM is Greg Zerr while its administrator is Tammi Baldock.