He has worked with multiple artists including Aerosmith, Sting, Bryan Adams, Meat Loaf, Foreigner, Cheap Trick, John Fogerty, Joe Bonamassa, Scorpions, and Curt Smith (Tears for Fears).

In the mid-1990s, Irwin went on to play with Mayfield, a band featuring Curt Smith of Tears for Fears, which led to a touring position as a keyboardist, vocalist and guitarist with Aerosmith (1997–2014), Sting, (2000–2001), Bryan Adams (2002), Cheap Trick (2012) and Joe Bonamassa (2016)[2] He has performed live with Maroon 5, Jimmy Page, Jeff Beck, Jonny Lang, Slash, Chris Botti, Alan Parsons, and Jessica Simpson.

Irwin has written songs for multiple artists including Aerosmith, Foreigner, Meat Loaf, and Scorpions.

In 2012 Irwin released his second solo album Get Me Home, which included guest artists Steven Tyler and Brad Whitford of Aerosmith, Chris Botti and Dean DeLeo of Stone Temple Pilots.

"[3][4] He appeared occasionally on The Real Housewives of New York City while she was a cast member on the reality show.