A right-handed pitcher, Meyer's professional career lasted for 16 seasons, including 319 games pitched over all or part of 13 years in Major League Baseball for the Chicago Cubs (1946–48; 1956), Philadelphia Phillies (1949–52), Brooklyn Dodgers (1953–55), Cincinnati Redlegs (1956), Boston Red Sox (1957) and Kansas City Athletics (1959).

[1] Initially signed by the Chicago White Sox as an amateur free agent in 1942, Meyer spent 1943 performing United States Army service during World War II.

While pitching for his camp team, Meyer was stricken with appendicitis, then contracted peritonitis; he was given a medical discharge and released by the White Sox organization.

In 1949, with the Phillies, he won 17 of 25 decisions with a 3.08 earned run average (seventh in the National League), as Philadelphia finished in the first division for only the second time since World War I.

[4] On May 6, 1961, Meyer served as a television color commentator alongside Bob Finnegan for a game between the Detroit Tigers and Chicago White Sox on CBS.