Chittenden, known as the "father of American biochemistry", was a professor at Yale University, and the house was declared a National Historic Landmark in 1975 in recognition of his importance.

[2][3] The Chittenden House is an irregularly shaped three-story brick structure with Queen Anne elements.

[3] The house was purchased by Russell Henry Chittenden in 1887, probably from its builder, and was to remain his home until his death in 1943.

His principal innovations revolved around developing techniques and an understanding of the digestive process, in particular the role enzymes played in the breakdown of complex protein molecules.

He also made early strides in the field of nutrition, setting the stage for later developments in that area.