[4] Madeley actively volunteered for Whizz-Kidz throughout her childhood and was part of the Kidz Board youth panel.
[5][6] As part of her work with Whizz-Kidz, at age 13, she visited Cherie Blair at 10 Downing Street to discuss fundraising and awareness.
[11][12] Madeley attended Thornleigh Salesian College and later studied English and creative writing with a focus on scriptwriting at Edge Hill University, and graduated with a First Class Honours degree.
She returned to the job after her BAFTA win, thinking there would not be enough roles for disabled actresses for her to make a career in acting.
[25] In 2021, she competed on Celebrity Best Home Cook[26] and played Throat in the television adaptation of Terry Pratchett's Discworld novel, The Watch.
[29][30] She also appeared in Tom Stern and Celyn Jones' film, The Almond and The Seahorse, inspired by Kaite O'Reilly's play of the same name.
[33] In late 2019 and early 2020, she played Barbara 'Buck' Buckingham in Teenage Dick at the Donmar Warehouse directed by Michael Longhurst.
[34] In September 2021, it was announced that she would star alongside Colin Baker and Bonnie Langford in the Big Finish Doctor Who audio dramas as a new companion of the Sixth Doctor, marine biologist Hebe Harrison.
She was cast as Shirley Anne Bingham in the television series' 2023 specials, which were written by Davies, who has returned as showrunner.