[8] According to one critic, Wisse's work has been characterized "by the sharpness of her insight, by her unwillingness to retreat from a skirmish and by the inability of even those who disagree with her to deny her brilliance.

Joyce Carol Oates described The Best Of Sholem Aleichem, a collection of short stories by Sholem Aleichem which Wisse edited with Irving Howe as, "Like all good anthologies... more than simply a heterogeneous collection of pieces linked by common theme or author: it is also a statement, an argument, an attempt at redefinition.

She wrote: Women's liberation, if not the most extreme then certainly the most influential neo-Marxist movement in America, has done to the American home what communism did to the Russian economy, and most of the ruin is irreversible.

By defining relations between men and women in terms of power and competition instead of reciprocity and cooperation, the movement tore apart the most basic and fragile contract in human society, the unit from which all other social institutions draw their strength.

In May 2014, a profile of Wisse in The Forward called her "one of the most forceful conservative voices in support of Israel, arguing that criticism of the state repeats ingrained habits of Jewish accommodationism and self-blame.

[20][21][22] In 1988, Alexander Cockburn wrote about Wisse's frustration with the discomfort American Jewish intellectuals felt regarding violence against Palestinians.

[26] In a November 2016 interview, Wisse stated that she voted for Donald Trump in the 2016 United States presidential election despite his being "16th on [her preferred] list of Republican candidates for president,"[27] Wisse endorsed Trump for re-election in 2020 in a Wall Street Journal op-ed.