Dom Rui Gomes da Silva (in Spanish, Ruy Gómez de Silva), 1st Prince of Eboli (27 October 1516 in Chamusca – 29 July 1573 in Madrid), was a Portuguese noble and one of King Philip II of Spain's main advisers.

In March 1526, he escorted Infanta Isabel of Portugal to Seville where she married Charles I of Spain.

In 1554 when his eldest brother John died, Rui inherited the lordship of Ulme and Chamusca.

In April 1559, he was one of the signatories of the Treaty of Cateau-Cambrésis which ended the Italian Wars with France.

His biggest political adversary was Fernando Álvarez de Toledo, 3rd Duke of Alba.