Ruy Pérez Ponce de León

- d. 1295) was a Spanish noble of the House of Ponce de León, in the service of the Kingdom of Castile.

He was the 15th Grand Master of the Order of Calatrava from 1284 to 1295 under King Sancho IV of Castile and further served as Mayordomo Mayor del Rey from 1293 - 1295, also under Sancho IV.

One of his brothers was es:Fernán Pérez Ponce de León I.

Prior to his election to grand master, he was the Comendador militar of Alcañiz for the Order of Calatrava.

He was elected to grand master in 1284, succeeding Juan González (served 1267–1284).

Cross of the Order of Calatrava .