She joined the "P&G" cosmetic model competition at age 14 and made her television debut the following year singing on the program, TK Music Camp.

In 1997, she appeared in the finale of medical drama Hoshi no Kinka and the special episode of Odoru Daisousasen before making her breakthrough performance in Fuji TV's comedy series Beach Boys, where she was awarded "Best Supporting Actress" at the 14th Television Drama Academy Awards.

In 1998, Hirosue reprised her role in the special episode of Beach Boys while also appearing in four other television dramas in the same year.

She also reunited for the fourth time on television with her frequent co-star Yutaka Takenouchi (they starred together in Long Vacation, Beach Boys and Seikimatsu no Uta) in Fuji TV's romantic comedy series Dekichatta Kekkon, starring as an expectant couple who did not know each other well before their one-night stand leading to the planning of a shotgun wedding.

The series also starred Hiroshi Abe who won Best Supporting Actor at the 30th Television Drama Academy Awards.

She reunited with her Summer Snow lead co-star, Tsuyoshi Dōmoto, in 2003's romance series Moto Kare.

Her portrayal as the initially flippant ex-girlfriend, Makoto Saeki, won her "Best Supporting Actress" yet again at the 38th Television Drama Academy Awards.

In 2007, she co-starred for the third time with Hiroshi Abe (her fellow actor in Dekichatta Kekkon and Haruka Naru Yakusoku) in the film Bubble Fiction: Boom or Bust.

[6] She co-starred in the 2010 film Flowers with Yū Aoi, Kyōka Suzuki, Yūko Takeuchi, Rena Tanaka and Yukie Nakama.

[14] On 7 June 2023, Shūkan Bunshun reported that Hirosue was allegedly having an extramarital affair with married Michelin star chef Shusaku Toba after being spotted entering the Cerulean Tower Tokyo Hotel together.