Since moving to the US, Cartwright had a recurring role on the television series Bones as the laboratory intern Vincent Nigel-Murray, until the death of his character in the season 6 episode The Hole in the Heart.
[3] He had a recurring role (as upper class Briton John Hooker) on season 3 of Mad Men, for which he, as part of Mad Men's ensemble cast, won the Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Drama Series in 2009.
[4] He played Gary Bell, an autistic character, on the Syfy television series Alphas (2011–2012).
[5] Cartwright's portrayal of Bell has earned praise from the neurological science community, crediting his complexity for eschewing stereotypes of autism previously displayed in mass media.
[6] In September 2016, Cartwright began a main role in the CBS sitcom Kevin Can Wait as Chale Witt.