As a senior in the 2012 season, he started all nine games he played in and was given an honorable-mention spot on the All-Conference USA team.

[7] He was placed on the active roster on October 22, 2013, only after the St. Louis Rams offered Griffin an opportunity to sign with them.

[8] To facilitate Griffin's signing to the active roster, linebacker Martez Wilson was waived.

[9] On September 2, 2014, it was announced that the Saints had waived Griffin and re-signed kicker Shayne Graham to the 53-man roster.

[14] In 2015 and 2016, Griffin was the Buccaneers' third-string quarterback behind Jameis Winston and Mike Glennon, and did not see any game action.

[18] In Week 14 of the 2019 season against the Indianapolis Colts, he made his NFL debut, starting the second half for the Buccaneers as Winston suffered a hand injury late in the second quarter.

[25][26] On November 10, 2023, Griffin signed with the Skorpions Varese in the Italian Football League (IFL).

Griffin led the Scorpions to an 8-0 regular season before losing 24-7 in the semi final of the playoffs to the Parma Panthers.

[27] On February 23, 2024, the Chicago Bears hired Griffin as an offensive assistant specifically working with the team's quarterbacks and wide receivers.