He played college football for the CSU Pueblo ThunderWolves and was selected by the Baltimore Ravens in the sixth round of the 2013 NFL draft.

[1] He was a Gene Upshaw Award finalist in his senior year with the CSU Pueblo ThunderWolves and finished fifth in the voting.

[9] On March 19, 2018, Jensen signed a four-year, $42 million contract with the Tampa Bay Buccaneers with $22 million guaranteed, making him the highest paid center in the NFL, as Ali Marpet moved from center to left guard to accommodate him.

[12][13] Jensen was among the three Buccaneers offensive linemen (joining Marpet and Tristan Wirfs) to be named to the 2022 Pro Bowl roster, a first for all three.

[14] On July 28, 2022, Jensen experienced a severe knee injury during Buccaneers training camp and had to be carted off the field.