Described by The New York Times as a "trombonist of vision and composure",[2] he leads Ryan Keberle & Catharsis,[3] Collectiv do Brasil, his All Ears Orchestra, the Big Band Living Legacy Project and co-leads the international chamber jazz ensemble, Reverso.

Keberle has performed with David Bowie, Maria Schneider, Wynton Marsalis, Darcy James Argue, Alicia Keys, and Sufjan Stevens, among others, and has appeared on seven Grammy Award-winning records.

A "relentlessly prolific sideman", Keberle has appeared on movie soundtracks for filmmakers including Woody Allen and in the pit for Broadway musicals such as In the Heights.

He was inspired by the tradition of the instrument in jazz history, as well as by the horn bands Chicago, Blood, Sweat & Tears, Tower of Power, and Earth, Wind & Fire.

Based in Brooklyn, he freelanced as a recording and performing musician in multiple genres — in addition to traditional and avant-garde jazz, Keberle played with Latin, R&B, and rock artists.

Composed of piano, bass, drums, two trombones, trumpet, French horn, and tuba, the Ryan Keberle Double Quartet's self-titled debut was released on Alternate Side in 2007.

[11] In 2012, after touring internationally with Sufjan Stevens, Keberle formed Catharsis, a pianoless acoustic quartet, with Mike Rodriguez on trumpet, Jorge Roeder on bass and Eric Doob on drums.

Keberle keeps wide-ranging company, working with everybody from Latin luminary Ivan Lins to compositional queen Maria Schneider to pop/R&B superstar Alicia Keys, but his raison d'être isn't diversification; he's all about touching the soul through sound means.

He has led clinics throughout the New York City public school system as part of the American Composer Orchestra's educational outreach program, and has guest-conducted local and all-region jazz bands.

The album received critical praise from the NY Times saying “all those tones give the lovely, splayed-out energy, turning his sighing compositions, into big, open canvases”[15] and The Wall Street Journal said the “wordless vocals, lyrics and solos emerge from gorgeous weaves of musical textures.”[16] Keberle was featured in Downbeat Magazine's Blindfold Test[17] in January 2020.

[18] The newly formed quartet performed numerous gigs in and around São Paulo and immediately recognized the chemistry amongst the collective’s musicians leading to the formation of Collectiv do Brasil.