North has written for several Marvel Comics series, including The Unbeatable Squirrel Girl, Power Pack, and Inhumans: Once and Future Kings.

[13] On January 21, 2013, Shiftylook.com launched Galaga, a comic written by North and illustrated by Christopher Hastings and colored by Anthony Clark, the creators of The Adventures of Dr.

On July 21, 2017, two of North's projects were awarded Eisner Awards: "Best Publication for Teens (ages 13-17)" for The Unbeatable Squirrel Girl (with Erica Henderson), and "Best Humor Publication" for Jughead (with Chip Zdarsky, Henderson, and Derek Charm).

[18][20] This graphic novel is described as a "dystopian fantasy" and is scheduled to be published in April 2023 by Penguin Teen.

In October 2024, at New York Comic Con, it was announced that North was heading up Marvel's 2025 event One World Under Doom.

[28] A collection of short stories titled Machine of Death was released October 2010 through Bearstache Books.

[29] The book, featuring stories and illustrations by various authors and artists, was based on a Dinosaur Comics comic by North of December 5, 2005, with the premise of a machine that predicts the manner of a person's death accurately but in a difficult to understand manner.

[36][37] In 2018, Riverhead Books published Ryan North's How To Invent Everything: A Survival Guide for the Stranded Time Traveller, a nonfiction guide to technology based around the fictional premise of a time machine stranding the reader in the past, with illustrations by Lucy Bellwood.

[39][40] In 2019, North helped develop the story and writing for an iOS game app called AVO!

[41] by Playdeo Limited [42] North wrote the 2021 action-adventure video game Lost in Random, published by Electronic Arts.

His parents are Anna and Randall North[58][non-primary source needed] and said in an interview that he has a younger brother, Victor.

[4] In an interview, North said that his family lived in rural Osgoode and there was not a lot to do, so spent much of his time on the computer.

In 2006, a group of teenage girls in Ravenna, Ohio were arrested after they created and distributed several of these blocks, over fears they were bombs.