[4] The Los Angeles Dodgers selected Pepiot in the third round of the 2019 MLB draft; he became the highest-drafted Butler player in program history.

He finished the season with 13 appearances (10 starts) between the two levels, recording no decisions with a 1.93 ERA and 31 strikeouts in 23.1 innings pitched.

[7][8] He began the 2021 season with the Double-A Tulsa Drillers, where he went 3–4 with a 2.87 ERA, 0.94 WHIP, and 81 strikeouts over 59+2⁄3 innings pitched before being promoted to the Triple-A Oklahoma City Dodgers.

[12] On July 5, Pepiot picked up his first major league win against the Colorado Rockies.

[14] On December 16, 2023, the Dodgers traded Pepiot and Jonny DeLuca to the Tampa Bay Rays in exchange for Tyler Glasnow and Manuel Margot.