Tucker made his major league debut on June 8, 2008, for the Marlins against the Cincinnati Reds, allowing one run in five innings to pick up the win.

He missed most of 2009 with injuries, including a knee surgery to repair a torn quad, and appeared in only 6 minor league games.

He returned in 2010 to start for the class-AAA New Orleans Zephyrs and the class-A Jupiter Hammerheads, where he was 1–3 with a 6.00 ERA in 23 relief appearances.

On November 16, 2011, Tucker was signed to a minor league contract, with a spring training invite, by the Los Angeles Dodgers.

He pitched in only 4 games for the Isotopes and spent much of the time on the disabled list, before having shoulder surgery to repair a torn labrum on June 5, 2012.