Undrafted but establishing as a hard-hitting offensive defenseman, Wilson was invited as a free agent to the 2006 St. Louis Blues training camp before returning to the OHL.

[3] Overlooked in the NHL Entry Draft, Wilson was invited to the 2007 Philadelphia Flyers training camp on September 16, before returning for his final junior season as captain with the Sting in 2007–08.

[4] Alongside future first overall NHL draft pick, Steven Stamkos, Wilson led the Sting to the second round of the Western Conference finals finishing with a career high 64 assists and 71 points in 58 games as the leading scoring defenseman in the OHL for the second consecutive season.

[14] Wilson remained with the Avalanche and quickly established himself as an aggressive open ice hitter, most notably gaining league-wide attention after delivering a big hit to New Jersey Devils star Patrik Eliáš.

Over a month later, Wilson headed overseas to sign for the remainder of the season with Russian club, Ak Bars Kazan of the Kontinental Hockey League, on November 6, 2015.

Unsigned over the summer, Wilson belatedly signed a one-year deal with Swiss club, HC Lugano of the NLA on September 13, 2016.