[9] On 30 August, it was announced that MacDonald-Gay had signed a senior contract with South East Stars, and she made her full debut for the team later that day, in a Charlotte Edwards Cup match against Central Sparks.
[11] In 2022, she played five matches for the side, across the Charlotte Edwards Cup and the Rachael Heyhoe Flint Trophy, and made her maiden List A half-century, scoring 54* against Lightning, as well as taking six wickets.
[18][19] In 2024, she played 21 matches for South East Stars, across the Rachael Heyhoe Flint Trophy and the Charlotte Edwards Cup, taking 29 wickets with a best bowling of 5/31.
[25] On 25 June 2024, MacDonald-Gay received her first call-up to the senior England squad for a home three-match one-day international series against New Zealand.
[26][27] After not playing in the New Zealand series, MacDonald-Gay made her One Day International debut for England against Ireland at Stormont in Belfast on 7 September 2024, taking 1/30 in the eight overs she bowled.