As of January 2008, the airport has had scheduled international flights to Dublin and London–Stansted, in addition to its domestic connection with Warsaw.

On 9 March 2022, the United States deployed two MIM-104 Patriot surface-to-air missile systems to the airport in what it called a "precautionary defensive move.

"[7] On 5 March 2022, US Secretary of State Antony Blinken landed in Rzeszów to meet with Ukrainian Minister of Foreign Affairs Dmytro Kuleba in Ukraine.

The President of the United States Joe Biden landed on Air Force One in Rzeszów twice, on 25 March 2022 to meet American troops, and on 19 February 2023, on the way to Kyiv.

The airport also features scheduled bus services from MPK and MKS to Rzeszów city centre.