Sântimbru (Hungarian: Marosszentimre; German: Sankt Emmerich) is a commune located in Alba County, Transylvania, Romania.

It has a population of 3,032 as of 2021, and is composed of five villages: Coșlariu (Koslárd), Dumitra (Demeterpataka), Galtiu (Gáldtő), Sântimbru, and Totoi (Táté).

The national road DN1 and the European route E81 pass through the western side of the commune.

The Podu Mureș train station in Coșlariu serves the CFR main line 300, which connects Bucharest with the Hungarian border near Oradea.

Ethnic Romanians have been in the majority since the 19th century, and today, the inhabitants mainly build bricks and raise poultry.