It includes a number of blocks of Archean basement, separated by orogenic belts.
The belts are characterized by sedimentary basins and passive continental margins containing granite intrusions.
The São Francisco Craton around 1.0 Ga ago was in the south of the supercontinent Rodinia, and after the fragmentation of Rodinia in the late Proterozoic (700 Ma) became a member of the supercontinent Gondwana until it fragmented in the Jurassic (about 180 Ma).
The subsequent opening of the Atlantic Ocean left Southern Africa in the Congo Craton and the São Francisco block in South America.
The ancient Paleoproterozoic orogenic belts of the São Francisco Craton contain many economically important minerals, particularly those containing iron (as in the Iron Quadrangle) and gold, and are a major source of income for the mining industry in Brazil.