The São Francisco National Forest is in the municipality of Sena Madureira in the state of Acre.

The Chico Mendes Extractive Reserve is some distance to the south, on the opposite side of the Iaco River.

[3] The São Francisco National Forest was created by federal decree on 7 August 2001.

[1] The consultative council of the Macauã and São Francisco national forests was created on 17 January 2002.

On 17 August 2008 the Instituto Nacional de Colonização e Reforma Agrária (National Institute for Colonization and Agrarian Reform, INCRA) recognised the forest as an agro-extractive project for 25 families.