São Miguel das Missões is a municipality in Rio Grande do Sul state, southern Brazil.

San Miguel Mission is within Santo Ângelo Microregion, and the Riograndense Northwest Mesoregion.

The town grew around the Spanish colonial Jesuit Reduction, Mission San Miguel Arcángel, founded in 1632.

In 1937 the SPHAN was created and in the same year, the architect Lucio Costa was sent to Rio Grande do Sul to analyze the remains of the ruins of the Seven Peoples of the Missions, and propose measures.

Currently listed in the museum's collection are religious images from the time of installation of the Jesuit missions in the region.