Its current and seventh metropolitan archbishop is Dom Odilo Pedro Cardinal Scherer, appointed by Pope Benedict XVI on March 21, 2007,[2] and installed on April 29 of the same year.

It was ready for its dedication on the 400th anniversary of the foundation of the then humble villa of São Paulo by Chief or Cacique Tibiriçá and the Jesuit priests Manuel da Nóbrega and José de Anchieta.

Construction began in 1913 on the demolished colonial cathedral site following the project of German architect Maximilian Emil Hehl, who designed a Neo-Gothic structure.

Work proceeded slowly, and the inauguration of the new Cathedral happened only in 1954, with the towers still unfinished, but in time for São Paulo's Fourth Centenary celebration.

Tibiriçá was the cacique (chieftain) of the Guaianás tribe who, in the 16th century, welcomed the first Jesuits to the Piratininga Plateau and whose aid made the foundation of São Paulo possible.

In 2004, the human remains of Bartolomeu de Gusmão (1685–1724), a Jesuit from the former Portuguese colony of Brazil and innovator of lighter-than-air airship design, were transferred to the crypt.

[3] The window frames were made in granite, by a stonework company called Palici-Baccaro, founded by family members of Italian immigrants in the 1940s, having as partners Angelo Palici and João Baccaro, located at Oratório street, near Fernando Falcão street, region of the Mooca, São Paulo, Brazil, that later would give origin to Baccaro Marbles and Granites, traditional company in the local market.