São Tomé and Príncipe competed at the 2019 African Games held from 19 to 31 August 2019 in Rabat, Morocco.

[1] Agate de Sousa competed in the women's 100 metres and she finished in 26th place in the heats; she did not advance to the semifinals.

[2] Esmaiel Freitas competed in the men's 200 metres event and he finished in 42nd place in the heats.

[3] Gilberto Leite competed in the men's 800 metres event and he finished in 29th place in the heats.

[4] Dúdú Cruz was scheduled to compete in the men's long jump event but he did not start.