Sé is the name of the most central borough in the city of São Paulo, in Brazil, divided in eight districts.

Also located in the Sé are the Pátio do Colégio, site of the foundation of the city in 1554, the São Paulo stock exchange (the Bovespa), the mayor's palace and other historical buildings, including the Municipal Theater of São Paulo, the São Paulo Music Hall (Sala São Paulo) and the central railway Luz Station (Estação da Luz).

Immigrant groups established in the Sé borough include Italians (in Bela Vista), Japanese (in Liberdade), and Jews (in Bom Retiro).

The neighbourhood (and the later city) has developed between the three ancient churches of Our Lady of Mount Carmel, Saint Benedict and Saint Francis of Assisi (which part of it was expropriated by Emperor Pedro II for the establishment of the Law School).

This borough is also an important college center with the very traditional Law School of the University of São Paulo and Mackenzie University, founded by North American Presbyterian missionaries in the 19th century.