Sédhiou region (retroactively called Middle Casamance) is a region of Senegal located in the southwest of the country in the natural region called Casamance.

It was historically a department of the Kolda region until 2008.

It also shares borders with the Gambia in the north and Guinea-Bissau in the south.

Sédhiou region has three departments:

This Senegal location article is a stub.