The intensity of her images, both in colour and replicative design, is sometimes interpreted as a reflection of her own psyche, walking a tightrope between ecstasy and mental illness.
In addition to her arduous day jobs, Louis painted by candlelight, largely in secret isolation, until her considerable body of work was discovered in 1912 by German art collector Wilhelm Uhde.
They only re-established contact in 1927 when Uhde – back in France and living in Chantilly – visited an exhibition of local artists in Senlis and, seeing Louis's work, realized that she had survived and her art had flourished.
Under Uhde's patronage, Louis began painting large canvases, some of them two meters high, and she achieved prominence as the naïve painter of her day.
In 1929, Uhde organized an exhibition, "Painters of the Sacred Heart," that featured Louis's art, launching her into a period of financial success she had never known – and was ill prepared to manage.
Louis was an artist consumed by an irrepressible urge to create, "this famous internal necessity of which Kandinsky spoke", terms employed by Bertrand Lorquin, conservator of the Musée Maillol in his introduction to the exhibition "Séraphine Louis dite Séraphine de Senlis" at the Musée Maillol in Paris, which ran from 1 October 2008 to 18 May 2009.