In 2005, Beltrame was selected by the team leader Georges Goven to play with Mary Pierce, Amélie Mauresmo and Nathalie Dechy for the semifinals of the Fed Cup against Spain when teammate Virginie Razzano was injured and players Marion Bartoli and Émilie Loit were suspended.

On 10 July 2006, Beltrame (as Séverine Brémond) achieved a career-high singles ranking of world No.

65 after her success at the 2006 Wimbledon Championships, where she reached the quarterfinal of a Grand Slam event for the first time.

Beltrame entered the 2008 US Open as a wildcard, where she beat Julia Görges, Nicole Vaidišová and Tathiana Garbin.

She lost to eventual champion Serena Williams (2–6, 2–6) in the fourth round.