Brostrøm worked as a chief physician at Herlev Hospital and as an associate professor at the University of Copenhagen, before joining the Danish Health Authority.
[7] Following the COVID-19 pandemic, Brostrøm became a prominent public figure in Denmark,[8] where he played a key role in the Danish response to COVID-19, which has been described as "one of the most successful in Europe.
[17][18] Søren Brostrøm was born in Aarhus in 1965, the second son of two medical doctors; his mother a paediatrician and his father a cancer researcher.
[14] Brostrom said in a 2020-interview that "the tragedy has left an everlasting mark on me" and that life after his father's death was burdened by "both grief and a tough financial situation".
[28] He made a career in several Copenhagen hospitals as a gynaecological surgeon and was one of the leading doctors in Europe in performing a special robotic-assisted operation in which the top of the vagina is stitched open.
[29] After his medical training, Brostrøm worked in 2007 as an attending physician at the gynaecological-obstetric department at Aarhus University Hospital Skejby.
[30] For two years from 2009 to 2011, Brostrøm worked concurrently as an associate professor at the Department of Gynaecology and Obstetrics (now part of the Department of Clinical Medicine) at the Faculty of Health and Medical Sciences at the University of Copenhagen, and completed a Master of Public Administration (MPA) at Copenhagen Business School.
[20] In September 2011, Brostrøm joined the Danish Health Authority as the Director of the Department of Hospitals and Emergency management, with broad responsibilities for the national planning of specialized hospital services, emergency services and preparedness, communicable diseases, immunization and screening programs as well as national action plans in the field of cancer, cardiovascular diseases, mental health etc.
[29] Brostrøm came to public attention when the Danish Health Authority's HPV vaccination programme in 2014–15 experienced a sudden and large drop in uptake among the target group, girls and young women, who feared serious side effects.
Brostrøm took responsibility for inadequate communication and did so in an open and personal manner, which has also been characteristic of his appearance at numerous press conferences and interviews in connection with the handling of the COVID-19 pandemic.