The 9M82M missile is intended to defeat tactical, theater, and medium-range ballistic missiles, as well as aerodynamic targets at a range of up to 200 km.

The Antey-2500 system is mounted on a tracked cross-country vehicle equipped with self-contained power supply and navigation systems, as well as surveying and positioning equipment.

In early October 2016, a battery of Russian S-300V4 missile system was deployed to Syria,[9] at the Russian naval base in Tartus.

[10] In early December 2020, the system entered combat duty on the Kuril Islands.

[11] On August 18, 2023, a Ukrainian drone captured videos of HIMARS artillery rockets destroying S-300V4 surface-to-air missiles in the Russo-Ukrainian War.