S. F. Vilas Home for Aged & Infirmed Ladies is a historic multiple dwelling located at Plattsburgh in Clinton County, New York.

It was built in 1889-1890 and is a three-story, brick, monumental multiple dwelling structure in the Queen Anne style.

It features truncated hipped roofs with cross-gable wings, corbelled decorative chimneys, and bands of colored brickwork.

It was built as a 44-bed residence for aged and infirmed women.

This article about a historic property or district in Clinton County, New York, that is listed on the National Register of Historic Places, is a stub.